Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model
E. Sassaroli, B. O'Neill 
The Methodist Hospital Research Institute, Houston, TX, USA
Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor and decrease convection of drugs from the tumor margin. High intensity focused ultrasound (HIFU) has been shown ...
S. Hoyer, M. Bottig, F. Zekiri, G. Götzl, A.K. Brüstle, G. Schubert, A. Nador
Geological survey of Austria, Vienna, Austria
Geological Institute of Hungary, Budapest, Hungary
Temperature measurements of the subsurface are available due to hydrocarbon exploration in the project area, where the average drilling depth is about 2-4 km and the deepest well reaches about 8.5 km. Since the data is heavily uneven distributed, standard interpolation techniques did not deliver satisfying results. This is why numerical modeling was applied to assess the thermal regime of the ...
Heat Generation from H₂/D₂ Pressurization of Nanoparticles: Simulation of the Experiments on COMSOL Multiphysics®
A. Osouf, G. Miley, B. Stunkard, T. Patel, E. Ziehm, K. Kyu-Jung, A. Krishnamurthy
Department of Aerospace Engineering, University of Illinois at Urbana - Champaign, Urbana, IL, USA
Department of Nuclear, Plasma & Radiological Engineering, University of Illinois at Urbana - Champaign, Urbana, IL, USA
University of Illinois at Urbana - Champaign, Urbana, IL, USA
A COMSOL Multiphysics® model of our apparatus has been created in order to simulate the pressurizations of our nanoparticles by Deuterium. Using reference measurements during a cooling process, we calibrated the model so that its thermal aspects reflect the ones of our experimental set up. To reproduce the pressurizations, the following variables are parameters : the location of the heat ...
Modelling of a 5 Cell Intermediate Temperature Polymer Electrolyte Fuel Cell (IT-PEFC) Stack: Analysis of Flow Configuration and Heat Transfer
A.S. Chandan, A. Mossadegh Pour, R. Steinberger-Wilckens
Centre for Hydrogen and Fuel Cell Research, University of Birmingham, Birmingham, United Kingdom
University of Birmingham, Birmingham, United Kingdom
Polymer Electrolyte Fuel Cells (PEFCs) are a key technology in the advancement of society towards a low carbon future, in particular for use within the automotive sector. PEFCs are advantageous due to their low operating temperature (60-80 deg.C), quick start up times and responsiveness to load change. However, the requirement for expensive platinum, difficulty of water management and heat ...
A.R. Sánchez-Guitard, E. Ruiz-Reina
University of Málaga, Málaga, Spain
In this work, we study the design of a new integrated system for Solar Water Heating that combines the solar thermal energy collection (primary circuit) with the heat storage (secondary circuit) into the same device. We have performed different finite element method simulations using COMSOL Multiphysics®, for solving the equations of heat transfer (conduction and convection) and those of fluid ...
K. Cluff, H. Mehraein, B. Jayakumar
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA
Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...
Can we use Aquifers to Monitor Magma Chambers? Using COMSOL Multiphysics® to Investigate Subsurface Strain Changes and Their Effect on Hydrological Systems - new
K. Strehlow, J. Gottsmann, A. Rust
University of Bristol, Bristol, UK
Groundwater-bearing geological layers respond to and modify the surface expressions of magmatic activity, and they can also become agents of volcanic unrest themselves. Interpretations of unrest signals as groundwater responses to changes in the magmatic system can be found for many volcanoes and include a wide range of phenomena and suggested processes to explain them (e.g., Newhall et al., ...
A. K. Morozov ,
 Teledyne Marine Systems, North Falmouth, MA, USA
Marine Vibrators are a coherent type of sound source, which can be quieter and less harmful for marine habitants than traditional air-gun technology. Such source gives clearer, more precise and higher resolution imaging of the bottom properties due to the coherent signal and streamer array processing. Teledyne Marine Systems is developing a coherent seismic marine sound source technology ...
P. Qian [1, 2],
 University of Wisconsin - Madison, Madison, WI, USA
 SmartUQ, Madison, WI, USA
Uncertainty appears in many aspects of physical simulations including stochastic design parameters, hard-to-specify input distributions, probabilistic boundary and initial conditions, and unknown geometries. Uncertainty Quantification (UQ) has emerged as the science of quantitative characterization and reduction of uncertainties in both simulation and test results. Stretching across applied ...
P. K. Jain , J. D. Freels ,
 Oak Ridge National Laboratory, Oak Ridge, TN, USA
Engineering design studies of the feasibility of conversion of the High Flux Isotope Reactor (HFIR) from high-enriched uranium to low-enriched uranium fuel are ongoing at ORNL as part of an effort sponsored by the U.S. Global Threat Reduction Initiative program. HFIR is a very high flux, pressurized light-water-cooled and moderated, flux-trap type research reactor whose current missions are to ...