Artigos Técnicos e Apresentações

Aqui você encontrará apresentações realizadas nas Conferências de Usuários COMSOL de todo o mundo. As apresentações englobam pesquisas e produtos inovadores feitas por engenheiros e cientistas usando o COMSOL Multiphysics. Os tópicos abramgem uma grande gama de indústrias e aplicações, como elétrica, mecânica, escoamento e química. Use a função de busca "Quick Search" para encontrar apresentações na sua área de interesse.

Kinetics of Zebrafish Dorsoventral Patterning

B. Jordan, and P. Müller
Harvard University
Cambridge, MA

The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...

Material Characterization Method Development: From Education to Design Optimization

C. Morgan[1], N. Kenkare[1], M. Williams[2], A. Peterson[2], and D. Williams[2]
[1]Alcon Eye Care Division of Novartis R&D, Duluth, GA
[2]Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA

Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...

Computer Simulation of Drug Release Kinetics of Mauran-Chitosan Nanoparticle in COMSOL

S. Raveendran[1], S. Sukuvihar[2], S. Kumar[1], and T. Maekawa[1]
[1]Tokyo University
[2]Senshin Technologies

• Bionanotechnology is a stream of modern science that deals with the study of biotechnology & nanotechnology applications. • Drug delivery applications as a key area of research attains more critical approaches where the role of nanoparticles are inevitable. • Biocompatible, non-cytotoxic hybrid mauran- chitosan nanoparticles has been synthesized and the drug release kinetics were ...

Design of Microneedle Array for Biomedicine

N. Mane[1], A. Gaikwad[1]
[1]Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India

Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...

Multiscale Electromagnetic Modeling of Contractions in the Pregnant Uterus

V. Tidwell[1], P. LaRosa[2], M. Zhang[1], H. Eswaran[3], A. Nehorai[1]
[1]Department of Electrical & Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
[2]Monsanto Company, Technology Pipeline Solutions, St. Louis, MO, USA
[3]OB/GYN Department, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Uterine contractions during pregnancy are currently poorly understood – experts disagree on the mechanisms by which contractions propagate through the organ and the structural layout of the uterine muscle fibers. We have developed a multi-scale model of the uterus, at the cellular, tissue, and organ levels. By comparing simulated abdomen-level magnetic field readings from our model to clinical ...

Modeling Bioclogging Effects in Constructed Wetlands for Wastewater Treatment

R. Samso[1], N. Forquet[2], P. Molle[2], J. Garcia[1]
[1]Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
[2]IRSTEA, Freshwater Systems, Ecology and Pollution Research Unit, Villeurbanne, France

Horizontal-Flow Constructed Wetlands (HFCWs) are a particular type of biofilter, and as such they rely mostly on the activity of bacterial communities to treat wastewater. Bacterial growth in HFCWs induces dramatic changes in its hydraulic and hydrodynamic behaviour (bioclogging), which may eventually result in overland flow of wastewater. Consequently, clogging is the main cause of premature ...

Growth and Remodelling of Intracranial Saccular Aneurysms

A. Di Carlo[1], V. Sansalone[2], A. Tatone[3], and V. Varano[1]
[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
[3]DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy

We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...

Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...

Stochastic Modeling of Biological Systems – Ranking the Model Parameters of the Human Vocal Folds

D. Cook[1]
[1]New York University, New York, USA

Computational models of biological systems are becoming more and more common in medical research areas. Evidence of this can be found by examining the number of articles containing the term “finite element” in the expansive National Institutes of Health (NIH) digital research archive PubMed. Numerical modeling of biological systems allows the execution of “computational ...

Bending of a Stented Atherosclerotic Artery

H.C. Wong[1], K.N. Cho[1], and W.C. Tang[1]

[1]Department of Biomedical Engineering, University of California, Irvine, California, USA

Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...

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