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Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new

L. Saeeednia[1], H. Mehraein[2], F. Abedin[1], K. Cluff[2], R. Asmatulu[1]
[1]Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
[2]Department of Bioengineering, Wichita State University, Wichita, KS, USA

Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...

How Finite Element Analysis Revolutionized a 100-Year Old Equation

K. Carlson [1], J. Arle [1], J. L. Shils [2], L. Mei [1],
[1] Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
[2] Rush Medical Center, Chicago, IL, USA

In 1901 Weiss proposed an equation predicting activation of nerve fibers by electrical stimulation, used in neuroscience and neuromodulation, which applies electric fields to modify nerve behavior in neurological disorders. Weiss’ equation is relative to geometry, electrode array, tissue conductivities, and waveform since it uses electrode amplitude. We replicated a leading calibrated nerve ...

Numerical Simulations Demonstrate Safe Vitrification and Warming of Embryos Using the Rapid-i™ Device

B.O.J. Johansson[1][2], Y.A. Tarakanov[1], H.J. Lehmann[2], and S.P. Apell[1]

[1]Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
[2]Vitrolife Sweden AB, Västra Frölunda, Sweden

During cryopreservation of human embryos, ice crystal formation in the embryos or in surrounding media may cause cryodamage to them and can be lethal. A strategy to avoid this is the vitrification procedure when the embryo and the surrounding medium undergo the transition to glassy state rather than a crystalline one during cooling. Similarly, recrystallization in the embryo or the medium must ...

Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies

M.S. Yeoman[1], C. Quah[2], A. Cizinauskas[1], K. Cooper[1], D. McNally[5], B. Boszczyk[2]
[1]Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
[2]The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
[5]Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom

Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...

Understanding the Role of Nanomaterials in DNA Biosensors Through Finite Element Analysis

J. C. Kumaradas[1], A. Zhang[2], Y. D. Davletshin[1]
[1]Ryerson University, Toronto, ON, Canada
[2]University of Waterloo, Waterloo, ON, Canada

Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...

Microvascular Dysfunction in PAD Patients - new

K. Cluff[1], H. Mehraein[1], B. Jayakumar[2]
[1]Department of Bioengineering, Wichita State University, Wichita, KS, USA
[2]Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...

Push or Pull, How Does Silk Flow?

J. Sparkes [1],
[1] University of Sheffield, Sheffield, UK

Silk is one of the longest used and most recognizable textiles that we, as a society, use regularly. We see it as a luxury good, worn as an indicator of success and value. However, despite mankind having domesticated and farmed silkworms for millennia, we still know relatively little about the manufacturing process which converts the liquid silk into the fibers we are so familiar with. Increased ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Influence of Non-Newtonian Blood Viscosity on Wall Pressure in Right Coronary Arteries with Serial Stenoses

B. Liu [1]
[1] Monmouth University, West Long Branch, NJ, USA

Three dimensional mathematical models are developed to simulate the blood flows in patient specific right coronary arteries with two stenoses. Simulations are carried out with various flow parameters under physiological conditions. Both Newtonian and non-Newtonian blood viscosity models are applied in the simulations to examine the influence of non-Newtonian viscosity of blood on the wall ...

3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®

X.G. Li[1], H. von Holst[1][2], J. Ho[1], and S. Kleiven[1]

[1]Division of Neuronic Engineering, KTH, Stockholm, Sweden
[2]Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...