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Magnetic Fields and Materials for Medical Bone Reconstruction Assisted by Advanced Finite-Element Simulations

A. Sytcheva[1] and T. Herrmannsdörfer[1]
[1]Hochfeld-Magnetlabor Dresden, Forschungszentrum Dresden-Rossendorf, Dresden, Germany

We address the use of magnetic fields, forces, and materials for medical purposes. In particular, the treatment of osteochondral lesions is aimed for. To support ongoing activities in this field of research, last advances in using Finite Element Analysis (FEA) for the simulation of relevant processes, like magnetic targeting and magnetic fixation are reported. The availability of advanced ...

Simulation of Radiation Dose Response in Phantom for CT

H. Chen-Mayer[1], R.E. Tosh[1]
[1]National Institute of Standards and Technology, Gaithersburg, MD, USA

The radiation dose produced by an x-ray CT scanner to the patient is conventionally referenced to measurements performed by an ionization chamber in a phantom. On a fundamental level, the radiation absorbed dose, J/kg, can be determined directly by the temperature rise in the absorbing material. We model the temperature response in a high density polyethylene (HDPE) phantom. Use of ...

Deformable Image Registration for Pleural Photodynamic Therapy

B. Liu[1], T. C. Zhu[1]
[1]Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time ...

Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new

K. Cluff[1], H. Mehraein[1], G. Jayakumar[2]
[1]Bioengineering, Wichita State University, Wichita, KS, USA
[2]Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...

Design and Strain Analysis of Artificial Femoral Head and Stem

N. M. Sundaram[1], M. Sneha[1], A. Kandaswamy[1], R. Nithya[2]
[1]PSG College of Technology, Coimbatore, Tamil Nadu, India
[2]Dr. N.G.P. Institute of Technology, Coimbatore, Tamil Nadu, India

The majority of elderly patients are subjected to hip bone replacement due to dislocation of bone, mechanical failure and infection. The life time of the implant varies from patient to patient depending on their daily physical activity. Once the implant fails, re-operation of hip bone replacement is performed. In United States, there are approximately 18 revision hip replacements performed for ...

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Flow-induced Vibrations of the Uvula and its Implication on Snoring

J. Xi[1], Q. M. Mohamad[1], Y. E. Yuan[1], J. Rohlinger[1]
[1]Mechanical and Biomedical Engineering, Central Michigan University, Mount Pleasant, MI, USA

1. Flow-induced uvula deformation considerably altered the flow dynamics inside the nose. 2. For a weak soft palate, complete flow occlusion can occur (sleep apnea). 3. Vibration of the airway structures is crucial to better understand snoring generation mechanisms and breathing-related disorders.

First Approach Toward a Modeling of the Impedance Spectroscopic Behavior of Microbial Living Cells

D. Rauly [1], P. Xavier [1], E. Chamberod [2], J. M. F. Martins [3], J. Angelidis [4], H. Belbachir [5]
[1] IMEP-LAHC, Universite Grenoble Alpes, France
[2] IUT, Universite Grenoble Alpes, France
[3] LTHE, Grenoble Alps University - CNRS - IRD, France
[4] LEAS, St. Ismier, France
[5] HBA Biotech SA, Grenoble, France

The subject of the interactions between electromagnetic (EM) fields and living cells is a strong issue for several decades [1]. Large number of works have been done to study the EM field penetration and inner induced currents in living microorganisms. Relevant information to be collected deals with level and frequency of the EM signal that may affect the development of the considered cells. The ...

Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

N. P. Uth [1], J. Mueller [2], B. Smucker [3], A. Yousefi [1],
[1] Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH, USA
[2] Research Computing Support, Miami University, Oxford, OH, USA
[3] Department of Statistics, Miami University, Oxford, OH, USA

Introduction: Bone tissue has a limited ability for regeneration; critically sized defects cannot self-heal and require medical intervention. Bone tissue engineering (TE) circumvents this issue by growing replacement bone tissue from the patient’s own cells inside scaffolds. TE scaffolds are porous constructs that act as a support structure during bone regeneration and helps cells attach and ...

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...