L. Weng , F. Ellett , J. F. Edd , M. Toner [1,2],
 Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
 Shriners Hospital for Children, Boston, MA, USA
Array-based technologies are important for many applications in drug discovery, microbiology and cell biology. A large-scale array of single cells allows high-throughput monitoring of behaviors of individual cells in parallel, avoiding the lack of cell specificity inherent to bulk measurement methods. Here, we designed a passive-pumping microfluidic device for trapping cells in an array and used ...
H.C. Wong, K.N. Cho, and W.C. Tang
Department of Biomedical Engineering, University of California, Irvine, California, USA
Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...
Modeling of the Impact of Blood Vessels Flow on the Temperature Distribution During Focused Ultrasound Exposure
K.C.P. Li, B.E. O'Neill, and E. Sassaroli
Methodist Hospital Research Institute, Houston, TX, USA
Focused ultrasound systems guided by magnetic resonance imaging (MRI) and thermometry have recently made possible the non-invasive thermal ablation of benign tumors such as uterine fibroids in clinical practice. Much more work is however required in order to make this technology available for the treatment of other forms of cancer. One of the major difficulties is associated with the presence of ...
M. Cartas-Ayala, R. Karnik
Massachusetts Institute of Technology, Cambridge, MA, USA
Characterization of particles has numerous applications in science and diagnostics. Recently, particle passage through constrained microchannels has been proposed to characterize particles based on their passage velocity. Nevertheless, there is no clear understanding of how the physics in this system interact. Here we quantify the effects of the flow around the particle by simulating the passage ...
J. Sparkes ,
 University of Sheffield, Sheffield, UK
Silk is one of the longest used and most recognizable textiles that we, as a society, use regularly. We see it as a luxury good, worn as an indicator of success and value. However, despite mankind having domesticated and farmed silkworms for millennia, we still know relatively little about the manufacturing process which converts the liquid silk into the fibers we are so familiar with. Increased ...
J. Park , M. P. Vidal-Meza , R. Zhou , S. Barua , C. Wang ,
 Missouri University of Science & Technology, Rolla, MO, USA
A simulation was performed to investigate the flow behaviors of drug delivery nanoparticles in a tumor-on-a-chip microfluidic device, which mimics a tumor cell having endothelial cells with micro-sized gaps. The Navier-Stokes equation and the convection-diffusion equation were used to model the flow field and the time-dependent particle distribution in the device, respectively. We investigated ...
J.L. Smart, and M. Kaliszan
University of Kentucky, Paducah, KY, USA
Medical University of Gdansk, Gdansk, Poland
COMSOL Multiphysics® 4.0 was used to study conductive and convective heat transfer from the human eyeball to the surrounding air. Postmortem temperature decay curves were collected in eyeballs of numerous human corpses. Of course, these curves represent only a portion of the complete temperature decay curve, since the pathologist is able to start collecting temperature data only after some ...
E. Engström, B. Balfors, and R. Thunvik
Royal Institute of Technology, Stockholm, Sweden
In this study we evaluate transport, retention and subsistence of Escherichia coli (E. coli), a common fecal indicator bacteria, in a model (2x1m) of a constructed wetland. Transport occurs in the unsaturated and saturated zone. Inactivation is accounted for as a kinetic first-order process. Retention is assumed to be dominated by solid-air-water interface straining and is modeled with a kinetic ...
R. Santoprete, B. Querleux
L'Oréal, Paris, France
To better quantify the impact of the morphological and mechanical properties of the main constituents of the stratum corneum (SC, the outermost layer of the skin) on its overall mechanical behavior, we developed a biomechanical model of the SC at a cellular scale, based on in vitro morphological and mechanical data. The sensitivity analysis quantified the relative impact of the mechanical and ...
M. A. Chetoui , O. Boiron , A. Dogui , V. Deplano ,
 Université de Monastir, Ecole Nationale D'ingénieurs de Monastir; Ecole centrale Marseille, Marseille, France
 Aix-Marseille Université, CNRS, Ecole Centrale, Marseille, France
 Université de Monastir, Ecole Nationale D'ingénieurs de Monastir, Marseille, France
Intervertebral discs (IVD) are fibro-cartilages situated between vertebrae providing their joint flexibility. They play a major role in the transmission and absorption of load through the spine. The disc can undergo progressive structural and quantitative changes in its composition and morphology related to mechanical load applied to the spine which can lead to disc degeneration; this disease is ...