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Degradation of DNA in Plasma

Biotechnology is a rapidly growing area in the pharmaceutical sciences. One example of a clinical application is gene therapy, where it is possible to produce proteins in vivo, using the body’s own mechanisms for protein production. Major issues in gene delivery involve the transport of plasmid DNA (pDNA) to target sites and the conversion between different forms of pDNA. This example ...

Danckwerts Benchmark

This model compares the solution to the model equations of a tubular reactor using Danckwerts inlet and outlet conditions. A second almost identical model is defined with extra inlet and outlet sections where no reactions occur. The concentration at the beginning of the inlet section is fixed. The results with Danckwerts conditions and with fixed inlet concentrations are compared.

Parameter Estimation for Nonideal Reactor Models

Real reactors can be modeled as combinations of ideal reactors. In this example the so-called "Dead zone model" is utilized. Two ideal CSTRs with interchange are set up to model the real reactor. One CSTR represents the highly agitated region and the other the less agitated region. For this, two parameters relating the volume and exchange rate of the two regions need to be found by comparing ...

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