Artigos Técnicos e Apresentações

Aqui você encontrará apresentações realizadas nas Conferências de Usuários COMSOL de todo o mundo. As apresentações englobam pesquisas e produtos inovadores feitas por engenheiros e cientistas usando o COMSOL Multiphysics. Os tópicos abramgem uma grande gama de indústrias e aplicações, como elétrica, mecânica, escoamento e química. Use a função de busca "Quick Search" para encontrar apresentações na sua área de interesse.

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

Numerical Validation of the Efficiency of Dual-Frequency Radiofrequency Ablation

A. Candeo[1] and F. Dughiero[1]
[1]Department Electrical Engineering, University of Padova, Padova, Italy

Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...

Comparison of Mathematical Modeling of Laser-induced Thermotherapy (LITT) to Experimental Data: Determination of Optimal Laser Parameters

B. Wassmer1, R. Viard2, J. Zemmouri1, P. Rochon2, J. Rousseau2, and S. R. Mordon2
1Osyris SA, Hellemmes, France
2INSERM U703 - IFR 114, CHU Lille, Lille, France

Liver metastasis is a major problem in public health. Laser-induced interstitial thermotherapy (LITT) is a recently developed, minimally invasive technique for local tumor destruction within solid organs. This technique consists of inserting a laser fiber inside the metastasis. The study aimed to determine laser parameters (power, time, duty cycle) and fiber type (bare, diffusing) in order to ...

On the Simulation of the Metabolism in Mammalian Cells using Homogenization Methods

M. Hanke, and M. Cabauatan-Villanueva
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden

The simulation of the metabolism in mammalian cells becomes a severe problem if spatial distributions must be taken into account. Especially the cytoplasma has a very complex geometric structure which cannot be handled by standard discretization techniques. In the present paper we propose a homogenization technique for computing effective diffusion constants. This is accomplished by using a ...

Finite-element Modeling of Elastic Surface Modes and Scattering from Spherical Objects

O. Falou1, J. C. Kumaradas2, and M. C. Kolios1,2
1Dept. of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada
2Dept. of Physics, Ryerson University, Toronto, ON, Canada

In this work, backscatter from an elastic sphere was used to validate the computational model against analytical solutions (Faran theory).Agreements between analytical and finite element solutions were found in the scattered far-field over a range of frequencies of interest (10 - 70 MHz). Oscillations of the elastic sphere at various resonance frequencies (peaks in the power spectrum) were also ...

A Mean Field Approach to Many-particles Effects in Dielectrophoresis

O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy

One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...

Some Clinical and Computational Studies On Haemodynamics In Stenosed Artery

A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India

Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...

Microstimulation in The Brain: Does Microdialysis Inuence the Activated Volume of Tissue?

D. Krapohl[1][3], S. Loeffler[2], A. Moser[2], and U.G.Hofmann[1]

[1]Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
[2]Institute for Neurology, University of Luebeck, Lübeck, Germany
[3]Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden

Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.

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